Upstream Biosciences Inc. ~ Press Releases

PRESS RELEASE - APRIL 3, 2006

Upstream Biosciences Inc. announces Provisional Patent filing of Prostate Cancer Biomarkers

April 3, 2006 - Upstream Biosciences Inc. (OTCBB:UPBS) ("Upstream" or "the Company"), an emerging leader in the field of genetic diagnostics for cancer and the prediction of drug response, has announced today the provisional patent filing of prostate cancer biomarkers that could be useful for determining patients with a genetic risk of developing prostate cancer.

Upstream intends on using its prostate cancer genetic markers to develop diagnostic tests to complement the existing Prostate Cancer Antigen (PSA) screening method. The PSA test is the most common test for prostate cancer. The Centers for Disease Control reported that 75 percent of men aged 50 and older reported that they have undergone PSA testing at least once.

According to the National Institute of Cancer, the PSA test can fail to detect prostate cancer in some patients and lead to unnecessary biopsies for many others. Only 25 to 30 percent of men who have a biopsy due to elevated PSA levels actually have prostate cancer.

Upstream's diagnostic markers could decrease the number of unnecessary biopsies and increase the likelihood of early detection by identifying which patients have a genetic risk of developing prostate cancer.

According to the American Cancer Institute, prostate cancer is the second leading cause of cancer death in men in the US.

"We are hopeful that our prostate cancer research may reduce unnecessary biopsies and provide relief to the many men who face uncertainty each year," says Upstream CEO Joel Bellenson.

Upstream is developing diagnostic tests that may aid in the early detection of cancer by identifying individuals with disease susceptibility. Upstream is also developing diagnostic tests that may determine whether a drug will be useful or harmful to an individual patient based on their genetic profile. According to the Journal of the American Medical Association, each year 100,000 people die in the United States due to adverse reactions to prescription drugs.

For more information, please contact Samantha Haynes at 1-800-539-0289 or info@upstreambio.com.

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