Upstream Biosciences Inc. ~ Press Releases

PRESS RELEASE - MARCH 28th, 2007

Upstream Biosciences Inc. announces Provisional Patent filing of Prostate Cancer Prognosis Biomarkers

March 28, 2007 - Upstream Biosciences Inc. (OTCBB:UPBS) ("Upstream" or "the Company"), an emerging leader in the field of genetic diagnostics for cancer and the prediction of drug response, announces a provisional patent filing of prostate cancer biomarkers that could be useful for determining the course of treatment for prostate cancer patients. This filing meets the Company’s fourth milestone related to the recent financing announced March 5, 2007.

According to the Mayo Clinic, when a biopsy confirms the presence of prostate cancer, the next step, called grading, is to determine the aggressiveness of the cancer. The most common cancer grading scale runs from 1 to 5, with 1 being the least aggressive form of cancer. These numbers, known as Gleason scores, may be helpful in determining which treatment option is best. Upstream’s genetic markers combined with the Gleason scores could help determine if a patient is likely to have an aggressive form of prostate cancer. According to the Canadian Cancer Society, the Prostate Specific Antigen (PSA) test, the most commonly used test for prostate cancer screening, does not discriminate between cancers that require treatment and those that do not. This can result in unnecessary treatment with severe side effects such as impotence, urinary incontinence and death.

"Our genetic markers could help physicians determine the best course of treatment for prostate cancer patients," says Upstream CEO Joel Bellenson. “Our technology could complement existing tests used for prostate cancer prognosis.”

Upstream is developing diagnostic tests that may aid in the early detection of cancer by identifying individuals with disease susceptibility. Upstream is also developing diagnostic tests that may determine whether a drug will be useful or harmful to an individual patient based on their genetic profile. According to the Journal of the American Medical Association, each year 100,000 people die in the United States due to adverse reactions to prescription drugs.

For more information, please contact Samantha Haynes at 1-800-539-0289 or info@upstreambio.com.

Media Contact:
David Libby at 510.868.4903 or cell 510.377.1466 or dlibby@libbycommunnications.com

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About Upstream Biosciences Inc.
Upstream Biosciences Inc. is an emerging leader in the field of genetic diagnostics for cancer and the prediction of drug response founded in 2004. Upstream discovers, develops, and licenses genetic based diagnostics for cancer susceptibility and drug response. Upstream's proprietary data mining pipeline enables it to locate and analyze genetic variations in the regions of DNA 'upstream' of the gene, the 'gene switches,' which control the quantities and timing of expression of the genes, and proteins important to disease and drug response.

Notice Regarding Forward-Looking Statements
This news release contains "forward-looking statements", as that term is defined in Section 27A of the United States Securities Act of 1933, as amended, and Section 21E of the United States Securities Exchange Act of 1934, as amended. Statements in this press release which are not purely historical are forward-looking statements and include any statements regarding beliefs, plans, expectations or intentions regarding the future. Such forward-looking statements include, among others, the expectation and/or claim, as applicable, that: (i) the Company will become an emerging leader in the field of diagnostics for cancer and the prediction of drug response; (ii) the provisional patent filing of the prostate cancer biomarkers could be useful for determining the course of treatment for prostate cancer patients; (iii) the Company’s genetic biomarkers combined with the Gleason scores could help determine if a patient is likely to have an aggressive form of prostate cancer; (iv) the Company’s genetic markers could help physicians determine the best course of treatment for prostate cancer patients; (v) the Company’s technology could complement existing tests used for prostate cancer prognosis; (vi) diagnostic tests currently being developed by the Company may aid in the early detection of cancer by identifying individuals with disease susceptibility; and (vii) diagnostic tests currently being developed by the Company may determine whether a drug will be useful or harmful to an individual patient based on their genetic profile. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others: (i) the risk that the Company does not execute its business plan; (ii) the inability of the Company to keep pace with technological advancements in the field of genetic diagnostics; (iii) the Company's inability to adequately protect its intellectual property or the Company's inadvertent infringement of third party intellectual property; (iv) the Company not being able to retain key employees; (v) competitors providing better or cheaper products and technologies; (vi) markets for the Company's products not developing as expected; (vii) the Company's inability to finance its operations or growth; (viii) inability to obtain all necessary government and regulatory approvals; and (ix) the inability to effectively market and commercialize the Company's technologies, including the establishment of viable relationships with third parties. These forward-looking statements are made as of the date of this news release and the Company assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements. Although the Company believes that the beliefs, plans, expectations and intentions contained in this press release are reasonable, there can be no assurance those beliefs, plans, expectations, or intentions will prove to be accurate. Investors should consider all of the information set forth herein and should also refer to the risk factors disclosed in the Company's periodic reports filed from time-to-time with the Securities and Exchange Commission and available at www.sec.gov.

DISCLAIMER FOR HISTORICAL PRESS RELEASES AND SEC FILINGS
This section contains historical and archived press releases and SEC filings for Upstream Biosciences Inc. The information in these press releases and SEC filings is historical in nature, has not been updated, and is current only to the date indicated in the particular press release or SEC filing. This information may no longer be accurate and therefore you should not rely on the any information contained in these press releases or SEC filings and should refer to our latest press releases and SEC filings. To the extent permitted by law, Upstream Biosciences Inc. and its employees, agents and consultants exclude all liability for any loss or damage arising from the use of, or reliance on, any such information, whether or not caused by any negligent act or omission.