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June 5, 2008
How Malaria Impoverishes Country
The Monitor (Kampala)
Until recently malaria was only known as the leadingkiller disease in Uganda and sub-Saharan Africa. But studies from the Ministry of Health indicate the disease is also the leading cause of poverty...
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May 2, 2008
Researchers from Canada and Uganda
breakthrough on new malaria drug
From Afrik.com
Canadian and Ugandan researchers at Makerere University said they
had recorded a breakthrough in their search for new drugs to treat
malaria, noting that initial toxicity tests in animals demonstrated the
safety of the drugs......
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(PDF 216k)
May 1, 2008
Breakthrough reported in malaria drug trial
From Monitor Online
Canadian scientists working with Ugandans at Makerere University have reported that their novel drug candidates to treat malaria have demonstrated good safety in their first toxicity tests in animals.....
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Aug 21, 2007
Computers Help Chemists Fight Emerging Infections
Science Daily
Computer analysis of existing drugs may be key to fighting new infectious
agents and antibiotic-resistant pathogens like deadly tuberculosis strains
and staph 'superbugs.' Researchers in Canada say the use of such "emergency
discovery" technology could save time, money and lives during a sudden
outbreak or a bioterrorism attack....
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(PDF 62k)
Feb 27, 2007
Genetics might engineer path to successful aging
By Fred Tasker
Miami Herald
Rapid advances in using human genes to diagnose, prevent and treat diseases
are bringing closer the time when many people can achieve their genetic
potential to live 100 years or longer, said Dr. Pascal Goldschmidt,
dean of the University of Miami Miller School of Medicine...
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Feb 14, 2007
Genetic Tests Pose Tailored Care
By Dinah Wisenberg Brin
Wall Street Journal
One of the nation's leading management companies of pharmacy benefits
aims to confirm whether genetic testing can help eliminate the life-threatening
and costly complications that many patients develop after starting a
prescription of the anticlotting drug warfarin...
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ARTICLE (PDF 27k)
Jan 5, 2007
PGx Tools Will Help Pharmas Mitigate Economic, Regulatory Challenges,
Tufts Report Predicts
By a GenomeWeb staff reporter
NEW YORK (GenomeWeb News) — Pharmaceutical companies this year
will rely on pharmacogenomic technologies to offset rising drug-development
costs, loss of patent exclusivity, and a tight reimbursement environment,
according to the Tufts Center for the Study of Drug Development...
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(PDF 47k)
Jan 4, 2007
Gene test could help lung cancer patients seeking treatment
Globeandmail.com
Scientists in Taiwan have developed a simple, five-gene test aimed at
showing which lung cancer patients most need chemotherapy, as similar
tests now do for people with breast cancer and lymphoma...
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ARTICLE (PDF 52k)
Dec 6, 2006
Peering Into the Future
By Claudia Kalb,
Newsweek
Genetic testing is transforming medicine—and the way families
think about their health. As science unlocks the intricate secrets of
DNA, we face difficult choices and new challenges...
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ARTICLE (PDF 81k)
Sept 3, 2006
Couples Cull Embryos to Halt Heritage of Cancer
By Amy Kolata,
New York Times
As Chad Kingsbury watches his daughter playing in the sandbox behind their suburban Chicago house, the thought that has flashed through his mind a million times in her two years of life comes again: Chloe will never be sick....
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ARTICLE (PDF 113k)
July, 11, 2006
A Tale of Two Drugs Hints at Promise for Genetic Testing
By Gina Kolata,
New York Times
With the exception of a few tests, the genetics revolution has not yet
happened. Now maybe, just maybe, it is imminent...
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ARTICLE (PDF 448k)
June, 23, 2006
11 Cousins Give Up Stomachs After Genetic Testing
Associated Press
Mike Slabaugh doesn’t have a stomach. Neither do his 10 cousins.
Growing up, they watched helplessly as a rare hereditary stomach cancer
killed their grandmother and some of their parents, aunts and uncles.....
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72k)
Oct. 26, 2005
Gene map points to personal drugs
Story from BBC NEWS
Scientists have completed a map of the most common differences in the
human genome, which could lead to personalised treatments for diseases.....
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Nov. 7, 2005
How Likely Are You To Get Sick?
By Catherine Arns
Business Week Online
A new DNA database could gauge your risk for disease
Gattaca, a science fiction movie released in 1997, portrays
a dystopian future in which a person's place in society is determined
by an analysis of his or her DNA, and the likelihood of disease is ascertained
at birth. The movie would seem to have little connection with reality
-- except that an international consortium has just completed the groundwork
for a version of this future....
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ARTICLE (PDF 73k)
Sept. 5, 2005
Putting the FDA Out Front
by John Carey
Business Week Online
Deputy Commissioner Dr. Janet Woodcock explains how the agency
has led the drive for personalized medicine
In her 19 years at the Food & Drug Administration, Dr.
Janet Woodcock has tackled some of the toughest issues facing the agency.
She led the Center for Drug Evaluation & Research -- the FDA's drug-approval
arm -- from 1994 to 2003. Since then, she has worked with industry on
a "critical path" initiative designed to improve the process
of drug development and also on an effort to understand how different
people respond differently to drugs...
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ARTICLE (PDF 105k)
Dec. 12, 2005
Treasures in the Trash
by Matthew Herper Robert Langreth
Forbes.com
What genetic researchers used to call junk DNA may conceal the most
important medical secrets of all.
When researchers began mapping the genome, aiming to decode
the entire human gene sequence, they expected to eventually locate 100,000
or more active genes. After completing the genome map in 2001, they
were startled to find that humans have only 25,000 active genes. The
lowly roundworm has almost as many (19,000)....
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ARTICLE (PDF 236k)
April 18, 2006
Liver Success
Emerging Enzyme Test Can Predict Drug Side Effects
By Lisa Barrett Mann, Special to The Washington Post
Adverse drug reactions — what most of us call side effects —
can range from annoying (headaches) to debilitating (diarrhea, vomiting)
to deadly. And certain drugs — especially psychiatric and cardiac
ones — are more apt to cause severe reactions. If only doctors
had a way to predict who's most susceptible...
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(PDF 81k)
April 14, 2006
WSJ.Com - New Genetic Tools May Reveal Roots Of Everyday Ills
By ANTONIO REGALADO, wsj.com
Rapid DNA Tests Can Search Many Variations at Once; Probing
Obesity, Memory
One Worry: Statistical Errors
In Switzerland, a group of college students and local laborers
sat down for a brief memory test a couple of years ago. They were given
30 words and then asked, five minutes later, to repeat them. On average,
they recalled eight.
Last summer, American scientists equipped with a powerful
new gene-testing technology gave this simple test an extra twist. DNA
samples of the best and worst word-recallers were flown to Phoenix,
where their DNA was checked with machines that can scour it for 500,000
genetic variations at lightning speed...
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(PDF 90k)
April 6, 2006
GSK's Allan Roses Says PGx Is Not Only Here, It's Already Paying
Off
By Bernadette Toner, editor, BioInform
BOSTON, April 6 (GenomeWeb News) - The era of pharmacogenomics has officially
begun, according to Allan Roses, senior vice president of genetics research
at GlaxoSmithKline, who showed examples of how his company is seeing
clear benefits from the application of genomic tools in its discovery
and development pipeline...
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(PDF 60k)
March 16, 2006
Bush Taps von Eschenbach, Outspoken Supporter of Genomics, to
Head FDA
By a GenomeWeb News staff reporter
President Bush yesterday nominated Andrew von Escehnbach to head the
US Food and Drug Administration, a potentially significant move for
the genomics community...
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(PDF 68k)
June 06, 2005
Good Genes
by Kerry A. Dolan
Forbs.com
Money & Investing
Do you want to invest in the DNA revolution? Don't wait for customized
drugs, which are years away. Buy shares
in a company that is using DNA for diagnostic work...
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ENTIRE ARTICLE (PDF 71k)
June 02, 2005
PGx and BIOMARKERS:
Current Role in Drug Development
by Felix W. Frueh, PhD
Associate Director for Genomics
Office of Clinical Pharmacology and Biopharmaceutics CDER/FDA
ACCELERATING ANTICANCER AGENT DEVELOPMENT AND VALIDATION...
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SLIDESHOW (PDF 1.1mb)
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